Amphotericin B

CAS:1397-89-3

Amphotericin-B is a member of the class of polyene antibiotics. It is an antifungal agent that is used both topically and systemically for various fungal infections, especially invasive infections caused by Candida. The drug acts by binding to steroidal alcohols in the cell membrane of susceptible fungi resulting in an increase of membrane permeability that allows leakage of the cellular contents.

Chemical Name:

[1 R -(1 R *,3 S *,5 R *,6 R *,9 R *,11 R *,15 S *,16 R *,17 R *,18 S *,19 E ,21 E ,23 E ,25 E ,27 E ,29 E ,31 E ,33 R *,35 S *,36 R *,37 S *)]-33- [(3-Amino-3,6-dideoxy- b - D -mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,-39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

Formula: C47H73NO17

Loss on Dry: Not more than 5%

Residue on ignition: Not more than 3%

Specification: USP