Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant, and anticancer properties. Apigenin content in different tissues and during leaf development was analyzed in celery cv. Shanghai yellow heart and cv. Ventura. Apigenin mainly accumulated in leaf and flower, and Shanghai yellow heart accumulated more apigenin than Ventura. The apigenin content increased rapidly in the middle stage of leaf development

Apigenin improved wound area, glycated Hb, serum glucose level and insulin.
Apigenin up-regulated IFG-1, TGF-β, VEGF-c, Ang-1 and collagen-1 mRNA expression.
TNF-α, IL-1β and IL-6 mRNA expression were down-regulated by Apigenin.
Apigenin induced angiogenesis via inflammatory mediator & growth factor modulation.

Brief:

Foods rich in apigenin include apples, endive, beans, broccoli, celery, cherries, cloves, grapes, leeks, onions, barley, parsley and tomatoes, while plant-derived beverages containing apigenin include tea and wine. Apigenin is natural flavonoid present in the leaves and stems of vascular plants, including fruits and vegetables.

Pharmacology:

Anticarcinogenic Activity.Antiviral agents for the treatment of HIV and other infections，inhibitor of MAP kinase，treatment of diseases including inflammatory bowel disease and skin conditions。Antioxidant and Pro-oxidant Effects.

Advanced Research:

Apigenin significantly induced glutathione transferase (GST) in Wistar rat heart, suggesting that it might function as a specific protectant against cardiotoxic agents.Anti-spasmodic in Parkinson's disease.