|CAS No.: 59865-13-3||
Our Cyclosporin A is US FDA and GMP available.
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Cyclosporine is a potent immunosuppressive agent that in animals prolongs survival of allogeneic transplants involving skin, kidney, liver, heart, pancreas, bone marrow, small intestine, and lung. Cyclosporine has been demonstrated to suppress some humoral immunity and to a greater extent, cell-mediated immune reactions such as allograft rejection, delayed hypersensitivity, experimental allergic encephalomyelitis, Freund’s adjuvant arthritis, and graft vs. host disease in many animal species for a variety of organs.
Cyclosporine, the active ingredient of Cyclosporine Oral Solution USP MODIFIED, can cause nephrotoxicity and hepatotoxicity. The risk increases with increasing doses of Cyclosporine. Renal dysfunction including structural kidney damage is a potential consequence of Cyclosporine Oral Solution USP MODIFIED and therefore renal function must be monitored during therapy. Care should be taken in using Cyclosporine with nephrotoxic drugs
Cyclosporin A Specification (USP Grade)
|Appearance||White crystalline powder; no visible evidence of contamination by foreign matter.||Standard Packing||100g/bag or per customer request|
|Purity||98.5% - 101.5%||Inventory||Normally we have Cyclosporin A in stock|
|Loss On Drying||≤ 2%|
|Heavy Metals||≤ 0.002%||Cyclosporin A physical parameters|
|Related Compounds||CAS No:||59865-13-3|
|Individual||≤ 0.7%||Molecular Weight||1202.61|
|Total||≤ 1.5%||Solubility||Soluble in Methanol, Ethanol, Acetone and Chloroform.|
|Synonym||Antibiotic S 7481F1, Cyclosporine|
|Certificate of Analysis||Cyclosporin A COA|
|Literature||Cyclosporin A literature|
|MSDS||Cyclosporin A MSDS|
|1.||Fruman et al (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc.Natl.Acad.Sci.U.S.A. 89 3686. PMID: 1373887.|
|2.||Brookemeier and Pfeiffer (1995) Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry 34 16440. PMID: 8845372.|
|3.||Nakata et al (1998) Evidence that cyclosporin A and dexamethasone inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells. Br.J.Pharmacol. 124 1425. PMID: 9723954.|
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