|CAS No.: 59787-61-0||Request for quotation|
Cyclosporin C is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
The selective and reversible insertion of pseudo-proline (?Pro) systems in cyclosporin C (CsC) featuring different C(2) substituents at the oxazolidine ring and its impact on the conformational and biological properties is described. The presence of a 5-membered ring exerts drastic effects upon the backbone conformation of CsC as demonstrated by NMR analysis. For example, the number of conformations, in particular in DMSO-d6, is strongly reduced and a cis 1-2 amide bond is induced when dialkylated at the C(2) position, resulting in a complete loss of the binding capacity to its receptor CypA. The reversibility of ?Pro insertion allows the temporary introduction of conformational constraints representing a new strategy in pro-drug design.
Cyclosporin C Specification
|Appearance||Colorless prismatic needles||Standard Packing||500mg/bag or per customer request|
|Purity (HPLC)||> 95%||Inventory||Normally we have Cyclosporin C in stock|
|Melting point||152 - 155 °C|
|Total impurity||< 5%||Cyclosporin C physical parameters|
|Heavy metals||< 0.02%||Formula||C62H111N11O13|
|Solubility||Soluble in Chloroform|
|Certificate of Analysis||Cyclosporin C COA|
|Literature||Cyclosporin C literature|
|MSDS||Cyclosporin C MSDS|
"Cyclosporin C is the main antifungal compound produced by Acremonium luzulae." By M Moussaif, P Jacques, P Schaarw?chter, H Budzikiewicz, and P Thonart. Centre Wallon de Biologie Industrielle, University of Liege, Belgium.
"Administration diluents differentiate Neoral from a generic cyclosporine oral solution" Writen by Kovarik J.M; Barilla D; McMahon L.; Wang Y; Kisicki J; Schmouder R
"Pseudoprolines (YPro): Targeting Bioactive Conformations of Cyclosporine Analogues" Writen by Luc Patiny, Michael Keller, Torsten W?hr, Jean-Fran?ois Guichou and Manfred Mutter. Institute of Organic Chemistry, University of Lausanne, BCH-Dorigny, CH-1015 Lausanne, Switzerland
"Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors." Writen by Ray JE, Keogh AM, McLachlan AJ, Akhlaghi F. Department of Clinical Pharmacology and Toxicology, Institute of Laboratory Medicine, Sydney, Australia
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