Epothilone A - R&S Pharmchem Co., Ltd

Epothilone A

CAS No.: 152044-53-6		Request for quotation
Epothilone A is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoA exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 20 nM for MDR CCRF-CEM/VBL100 cells). Epothilone A is a competitve inhibitor of 3H-paclitaxel binding with comparable IC50 to paclitaxel in displacement competition assays. EpoA causes cell cycle arrest at the G2/M transition leading to cytotoxicity.

Epothilone A Specification

Appearance	Off-white Crystalline powder	Standard Packing	500mg/bag or per customer request
Purity (HPLC)	95%	Inventory	Normally we have Epothilone A in stock
Melting point	95-98 °C (lit.)
		Epothilone A physical parameters
		CAS No:	152044-53-6
		Formula	C₂₆H₃₉NO₆S
		Molecular Weight	493.66
		Synonym	(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; (-)-Epothilone A; Epothilone A
		Solubility
		Structure




Certificate of Analysis	Epothilone A COA
Literature	Epothilone A literature
MSDS	Epothilone A MSDS

References:
1.	Schinzer, D. et al: "Total Synthesis of(−)-Epothilone A". Angew. Chem. Int. Ed. Engl. 36 (5): 523. (1997).
2.	Nicolaou, K.C. et al: "Total Syntheses of Epothilones A and B via a Macrolactonization-Based Strategy". J. Am. Chem. Soc. 119 (34): 7974 (1997).
3.	Höfle, G et al:. "Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution". Angew. Chem. 35 (1314): 1567 (1996).



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