Nigericin sodium salt

CAS: 28643-80-3

Delivery Time:1-2 working days

Synonames: Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464

Description: Nigericin: a polyether antibiotic and ionophore

Merck Index: 12,6633

Molecular weight: 746.94 g/mol

Molecular Formula: C40H67O11Na

Structure:

Apperance: white powder

Purity: 98% min by TLC

Melting point: 261¡ãC-265¡ãC (decomposition)

Solubility: Dichloromethane. Insoluble in water. Clear colorless solution at 10mg/ml Dichloromethane

Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation was described in the 1950s but in 1968 the structure could be elucidated by X-ray crystallography. The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464.

Nigericin acts as an H⁺, K⁺, Pb2⁺ ionophore. Most commonly it is an antiporter of H⁺ and K⁺.

In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions. Nigericin exhibits anti-HIV activity.

Reference:

1. S. Cafferel-Mendez, et. al. Reprod. Nutr. Dev. 27, 921, (1989)

2. K. Suzuki, et. al. Anal. Chem. 60, 1714, (1988)

3. S. Cafferel-Mendez et al. Reprod. Nutr. Dev. 27, 921, (1989)

4. K. Suzuki et al. Anal. Chem. 60, 1714, (1988) Parfenova, H., et. al. Am. J. Physiol. 277, C728-C738, (1999) Bevensee, M.O., et. al. J. Membr. Biol. 169, 131-139, (1999) Watanabe, N., et. al. Cytokine 10, 645-653, (1998)

5.Graven SN, Estrada-O S, Lardy HA (1966). "Alkali metal cation release and respiratory inhibition induced by nigericin in rat liver mitochondria". Proc. Natl. Acad. Sci. U.S.A. 56 (2): 654¨C8

Mark:

For research use only, not for human directly or drug.