Name: Vitamin B15
Synonym: Pangamic acid
CAS No.: 11006-56-7
Vitamin B15 is
water-soluble but its essential requirement in the diet has not yet
been proven. Research points to B15 aiding in lowering cholesterol
blood levels, aid in protein synthesis, neutralize liquor cravings
Vitamin B15 is
associated with B17.This cyanide-containing substance releases cyanide
only at a cancer site, thus destroying cancer cells while nourishing
Vitamin B15 can
is found in brewer's yeast, brown rice, pumpkin seeds and sesame seeds.
Vitamin B15 -
pangamic acid is required for:
Until further research is available, be careful of supplements containing
pangamic acid, calcium pangamate, DMG or B15.
Food sources of
Pangamic acid was first isolated in 1951 by Drs. Ernest Krebs, Sr.
and Jr., from apricot kernels, along with laetrile, termed vitamin
B17. At that time, as today, they were not sure whether it was essential
to life. Pangamic acid is also found in whole grains such as brown
rice, brewer's yeast, pumpkin and sunflower seeds, and beef blood.
Water and direct sunlight may reduce the potency and availability
of B15 in these foods.It is present in brown rice, brewer's yeast,
grains, as well as sunflower and pumpkin seeds.
Pangamic acid is mainly a methyl donor, which helps in the formation
of certain amino acids such as methionine. It may play a role in the
oxidation of glucose and in cell respiration. By this function, it
may reduce hypoxia (deficient oxygen) in cardiac and other muscles.
Like vitamin E, it acts as an antioxidant, helping to lengthen cell
life through its protection from oxidation. Pangamic acid is also
thought to offer mild stimulation to the endocrine and nervous systems,
and by enhancing liver function, it may help in the detoxification
Although many of these uses are not proven, there have been reports
of pangamic acid or DMG providing some benefits for a wide range of
symptoms, diseases, and metabolic problems. It may be useful for such
symptoms as headaches, angina and musculoskeletal chest pain, shortness
of breath, insomnia, and general stress-to be used, of course, only
after specific medical conditions are ruled out.
B15 has been shown
to lower blood cholesterol, so it could provide some nutritional support
for those with high serum cholesterol or cardiovascular problems or
to reduce heart and blood vessel disease risks. It may also help improve
circulation and general oxygenation of cells and tissues, so it may
be used with any decreased cardiac or brain functions. Pangamic acid
may be helpful in general for atherosclerosis and hypertension, America's
most common diseases.
In Europe vitamin
B15 has been used to treat premature aging, because of both its circulatory
stimulus and its antioxidant effect. It is felt to be a helpful protectant
from pollutants, especially carbon monoxide. Pangamic acid (and possibly
DMG) support for anyone living in a large polluted city or with a
high-stress lifestyle could be a wave of the future.
In Russia, a big
use of pangamic acid has been for treating those with alcohol problems,
possibly reducing the craving. It has been reported to diminish hangover
symptoms when alcohol has been abused. B15 has also been used to treat
fatigue, as well as asthma and rheumatism, and it may even have some
antiallergic properties. Some child psychiatrists have reported good
results using pangamic acid in disturbed children; it may help by
stimulating speaking ability and other mental functions. B15 may also
be useful in problems of autism.
More studies regarding
all claims of the benefits of pangamic acid must be done, of course,
to see which ones may be valid. But as of now, it certainly is a "vitamin"
or supplemental nutrient with potential health benefits and research
There are no known toxic effects from even high amounts of pangamic
acid; 50?00 mg. (and even more) taken three times daily have revealed
no side effects. There are reports of initial mild nausea with use
of pangamates at high levels, but this only lasts a few days.There
is limited information about deficiencies of pangamic acid. There
are no clear problems when it is absent in the diet, though some diminished
circulatory and oxygenation functions are possible. Decreased cell
respiration-that is, decreased oxygen use by cells-may influence many
other cellular functions which may lead to effects on the heart.
There is no RDA for pangamic acid. At the time of this writing, it
is not legal to distribute B15 in the United States, though it was
used as a supplement for some time in the 1970s. The most common form
of pangamic acid was calcium pangamate, but currently it is dimethyl
glycine (DMG), which may even be the active component that has been
hailed in the Soviet Union. Pangamic acid or DMG, when used, is often
taken with vitamin E and vitamin A. A common amount of DMG is 50?00
mg. taken twice daily, usually with breakfast and dinner. This level
of intake may improve general energy levels, support the immune system,
and is also thought to reduce cravings for alcohol and thus may be
very helpful in moderating chronic alcohol problems.